Insulin resistance relates to microvascular reactivity 23 years after preeclampsia
| Autor: | T.H.A. Ekhart, Louis L.H. Peeters, Julia J. Spaan, Angela Musella, Alphons J.H.M. Houben, Marc E. A. Spaanderman |
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| Přispěvatelé: | Interne Geneeskunde, RS: CARIM School for Cardiovascular Diseases, Promovendi ODB, Obstetrie & Gynaecologie, RS: GROW - R4 - Reproductive and Perinatal Medicine, MUMC+: MA Medische Staf Obstetrie Gynaecologie (9) |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Time Factors medicine.medical_treatment Hyperemia PORH Biochemistry Preeclampsia chemistry.chemical_compound Laser Doppler flowmetry Insulin resistance Pre-Eclampsia Pregnancy Internal medicine Laser-Doppler Flowmetry medicine Humans Insulin Reactive hyperemia Cardiovascular risk factors Netherlands Skin Glycated Hemoglobin Cardiovascular diseases [NCEBP 14] business.industry Cholesterol Microcirculation Area under the curve Cell Biology Blood flow Middle Aged medicine.disease Vasodilation C-Reactive Protein Cross-Sectional Studies Endocrinology chemistry Case-Control Studies Microvessels Female Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | Microvascular Research, 80(3), 417-421. Academic Press Inc. Microvascular Research, 80, 417-21 Microvascular Research, 80, 3, pp. 417-21 |
| ISSN: | 0026-2862 |
| Popis: | Preeclampsia, an endothelial disorder of pregnancy, is associated with an increased risk on cardiovascular diseases. Cardiovascular risk factors may mediate vascular dysfunction both during pregnancy but also later in life. This study aims to investigate microvascular reactivity, and its relationship with several cardiovascular risk factors, in women with a history of preeclampsia and controls. In this cross-sectional study we compared women with a history of preeclampsia (PE, n = 22) with women with uneventful pregnancies only (CON, n = 29) 23 years after their first delivery. Participants were matched for BMI, age and date of delivery. We assessed blood concentrations of fasting glucose, HbA1c, insulin, (total, HDL-, LDL-) cholesterol, triglycerides and CRP. Endothelial function was assessed by measurement of skin microcirculatory blood flow by Laser Doppler flowmetry at the dorsal and ventral site of the finger during post-occlusive reactive hyperemia (PORH). PE had higher fasting insulin levels and HOMA-IR compared with CON. The PORH response was similar in both groups. The area under the curve of PORH correlated with insulin and HOMA-IR at both sites, with BMI, triglycerides at the dorsal site and with CRP at the ventral site of the finger in PE and not in CON. In conclusion, 23 years after pregnancy we did not observe a difference in the microvascular hyperemic response between women with a history of preeclampsia and controls. Meanwhile, the results of our study suggest that insulin resistance and other cardiovascular risk factors are related to microvascular reactivity in middle-aged women with a history of preeclampsia. |
| Databáze: | OpenAIRE |
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