Sargassum hystrix as a Source of Functional Food to Improve Blood Biochemistry Profiles of Rats under Stress
| Autor: | Radipta Lailatussifa, Amir Husni, Alim Isnansetyo |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_treatment Inflammation cortisol brown algae medicine.disease_cause anti-stress 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Animal science Functional food In vivo Adaptogen medicine Sargassum hystrix Nutrition and Dietetics Chemistry Cholesterol Articles liver inflammation 030104 developmental biology medicine.symptom Diazepam 030217 neurology & neurosurgery Oxidative stress Food Science medicine.drug |
| Zdroj: | Preventive Nutrition and Food Science |
| ISSN: | 2287-8602 2287-1098 |
| DOI: | 10.3746/pnf.2019.24.2.150 |
| Popis: | This study was conducted to determine the influence of Sargassum hystrix powder (SHP) as an alternative source of functional food for treating in vivo stress by measuring levels of glucose, triacylglycerol, total cholesterol, and cortisol, and liver histopathology. Wistar rats aged 3 months and weighing 150~200 g were divided into 7 groups: normal control, fasting control, negative control (stress without adaptogen), and 4 experimental conditions (stress+0.18 mg/kg diazepam, stress+450 mg/kg pellet, stress+mixture of pellet with SHP 450 mg/kg, and stress+450 mg/kg of SHP). Intake of liquids and and body weight were measured daily. Blood samples were collected on day 0 (baseline), day 5, and day 10 to analyze levels of glucose, triacylglycerol, cholesterol, and cortisol. On day 10, rats were euthanized and livers were collected to observe the severity of inflammation. The results indicated that rats receiving SHP 450 mg/kg and the mixture of pellet with SHP 450 mg/kg showed a similar ability as those receiving diazepam 0.18 mg/kg to cope with stress, indicated by an improvement in all blood biochemistry parameters. Supplementation with SHP 450 mg/kg can be used as an alternative source of functional food for overcoming oxidative stress, as indicated by its ability to improve levels of blood glucose, triacylglycerol, total cholesterol, and cortisol, and to improve liver histology by decreasing severity of liver inflammation. |
| Databáze: | OpenAIRE |
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