| Autor: |
Tayyaba Hasan, Imran Rizvi, Edward V. Maytin, Mari Mino-Kenudson, Diane M. Simeone, Pushpamali De Silva, Yan Baglo, Mans Broekgaarden, Srivalleesha Mallidi, Huang-Chiao Huang, Michael Pigula, Sriram Anbil |
| Rok vydání: |
2023 |
| Popis: |
Supplementary Methods Supplemental Figure 1: The MIA-PaCa-2 + PCAF model exhibits histologic features consistent with desmoplasia 90 days post implantation Supplemental Figure 2: 1 μM calcipitriol activates the vitamin D receptor (VDR) in cancer associated fibroblasts Supplemental Figure 3: VDAR activation + PDP enable a 75% dose reduction in nal-IRI Supplemental Figure 4: Inhibition of the CXCL12/CXCR7 by CAL+PDP is lost by day 90 post-implantation Supplemental Figure 5: Calcipotriol and photodynamic priming cytotoxicity curves Supplemental Figure 6: MRC-5 conditioned medium does not affect the baseline metabolic activity of PDAC cell lines Supplemental Figure 7: PDP increases intratumoral nal-IRI via increased vascular and parenchymal permeability Supplemental Figure 8: Treatment with CAL+PDP+5 mg/kg nal-IRI induces global transcriptomic shifts in pancreataic tumors that correlate with a less aggressive and more responsive treatment profile compared to treatment with PDP+20 mg/kg nal-IRI |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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