Influence of brain death and associated trauma on solid organ histological characteristics
| Autor: | Luiz Felipe P. Moreira, Rafael Simas, Isaac Azevedo Silva, Diogo Haruo Kogiso, Cristiano de Jesus Correia, José Walber Miranda Costa Cruz, Luiz Fernando Ferraz da Silva, Paulina Sannomiya |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Pathology medicine.medical_specialty Morte Encefálica Brain Death Time Factors Hemodynamics Kidney Traumatismos Craniocerebrais Random Allocation medicine.artery Edema medicine Craniocerebral Trauma Animals Rats Wistar Lung Ratos business.industry Myocardium Abdominal aorta Balloon catheter Heart Patologia Rats Disease Models Animal medicine.anatomical_structure Isoflurane Liver Surgery Solid organ medicine.symptom business medicine.drug |
| Zdroj: | Acta Cirurgica Brasileira, Volume: 27, Issue: 7, Pages: 465-470, Published: JUL 2012 Acta Cirúrgica Brasileira v.27 n.7 2012 Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
| ISSN: | 1678-2674 |
| Popis: | PURPOSE: To evaluate histopathological alterations triggered by brain death and associated trauma on different solid organs in rats. METHODS: Male Wistar rats (n=37) were anesthetized with isoflurane, intubated and mechanically ventilated. A trepanation was performed and a balloon catheter inserted into intracraninal cavity and rapidly inflated with saline to induce brain death. After induction, rats were monitored for 30, 180, and 360 min for hemodynamic parameters and exsanguinated from abdominal aorta. Heart, lung, liver, and kidney were removed and fixed in paraffin to evaluation of histological alterations (H&E). Sham-operated rats were trepanned only and used as control group. RESULTS: Brain dead rats showed a hemodynamic instability with hypertensive episode in the first minute after the induction followed by hypotension for approximately 1 h. Histological analyses showed that brain death induces vascular congestion in heart (p |
| Databáze: | OpenAIRE |
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