Circadian-Regulated Cell Death in Cardiovascular Diseases
| Autor: | Tami A. Martino, Inna Rabinovich-Nikitin, Lorrie A. Kirshenbaum, Brooke Lieberman |
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| Rok vydání: | 2019 |
| Předmět: |
Time Factors
Circadian clock Autophagy-Related Proteins Apoptosis Disease 030204 cardiovascular system & hematology Necrosis 03 medical and health sciences 0302 clinical medicine Physiology (medical) Regulated cell death Autophagy Animals Humans Medicine Myocytes Cardiac Circadian rhythm 030304 developmental biology Chronotherapy 0303 health sciences Circadian Rhythm Signaling Peptides and Proteins business.industry Circadian Rhythm Cardiovascular Diseases Animal studies Apoptosis Regulatory Proteins Cardiology and Cardiovascular Medicine business Neuroscience Signal Transduction |
| Zdroj: | Circulation. 139:965-980 |
| ISSN: | 1524-4539 0009-7322 |
| DOI: | 10.1161/circulationaha.118.036550 |
| Popis: | Background: Over the past several years, a variety of human and animal studies have shown that circadian clocks regulate biological cardiovascular rhythms in both health and disease. For example, heart rate and blood pressure fluctuate over 24-hour daily periods, such that levels are higher in the morning and progressively decline in the evening. Methods and Results: It is interesting to note that the timing of the administration of various cardiac treatments can also benefit some cardiovascular outcomes. Circadian rhythms have been implicated in the pathogenesis of a number of cardiovascular diseases, including myocardial infarction, ischemia-reperfusion injury after myocardial infarction, and heart failure. Cell death is a major component of ischemia-reperfusion injury and posited as the central underlying cause of ventricular remodeling and cardiac dysfunction following myocardial infarction. It is notable that the time of day profoundly influences cardiac tolerance and sensitivity to cardiac injury. Conclusions: Herein, we highlight the novel relationship between circadian rhythms and homeostatic processes that governs cell fate by apoptosis, necrosis, and autophagy. Understanding how these intricate processes interconnect at the cellular level is of paramount clinical importance for optimizing treatment strategies to achieve maximum cardiovascular outcome. |
| Databáze: | OpenAIRE |
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