Incidence and outcomes of cutaneous angiosarcoma: A SEER population-based study
| Autor: | Allison T. Vidimos, Shlomo A. Koyfman, Giovanni Damiani, Brian R. Gastman, Thomas Chu, Sheena Tsai, G. Thomas Budd, Alice Frigerio, Rosalynn R.Z. Conic, Nikhil P. Joshi, Natasha Atanaskova Mesinkovska, Nicola Luigi Bragazzi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Skin Neoplasms Dermatologic Surgical Procedures Hemangiosarcoma Population Kaplan-Meier Estimate Dermatology 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Surveillance Epidemiology and End Results medicine Humans education Aged Retrospective Studies Aged 80 and over education.field_of_study Proportional hazards model business.industry Incidence Incidence (epidemiology) Hazard ratio Age Factors Neoplasms Second Primary Chemoradiotherapy Adjuvant Middle Aged Prognosis Neoadjuvant Therapy United States Confidence interval Survival Rate Chemotherapy Adjuvant 030220 oncology & carcinogenesis Localized disease Female Prior Primary business SEER Program |
| Zdroj: | Journal of the American Academy of Dermatology. 83:809-816 |
| ISSN: | 0190-9622 |
| Popis: | Background Cutaneous angiosarcoma (CAS) is a rare, malignant tumor of vascular mesenchymal origin accounting for less than 1% of all sarcomas. Objective To examine epidemiologic trends and outcomes in CAS. Methods In this retrospective, population-based study, patients with CAS were identified from the Surveillance Epidemiology and End Results database. Age, sex, and race-standardized incidence rates (IRs) were calculated. Survival was assessed with Kaplan-Meier curves and Cox proportional hazards models. Results Of 811 patients with CAS, 43% had a prior primary cancer. CAS IR for patients without prior primary cancers dropped from 5.88 per 100,000 in 1973 to 1984 to 2.87 per 100,000 in 2005 to 2014. In those with prior primary cancers, IR rose from 0.03 per 100,000 in 1973 to 1984 to 2.25 per 100,000 in 2005 to 2014. On multivariate analysis, patients older than 70 years of age had a higher risk of death compared with those younger than 50 years (hazard ratio, 2.16; 95% confidence interval 1.33-3.57; P = .002), and distant disease was associated with increased risk of death compared with localized disease (hazard ratio, 1.50; 95% confidence interval, 1.11-2.03; P = .008). Receipt of surgery and/or radiation therapy was not associated with survival. Limitations Potential selection and miscoding bias, retrospective nature. Conclusion CAS rates are rising among those with other prior primary cancers. Survival is not affected by current therapeutic strategies, highlighting the need for additional treatment options. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect