The effect of chronic stress on prenatal development of the central nervous system
Autor: | Damiana Borghi, Héctor Fernando Gauna, i. Monedero Cobeta, Lucila Giordana, María Cristina Romanini, Alicia Nélida Rolando, Debora Soledad Cots, Aída Andrea Bozzo, Tomás Díaz |
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Rok vydání: | 2014 |
Předmět: |
Central Nervous System
medicine.medical_specialty Histology Otras Ciencias Biológicas Central nervous system Hippocampus Biology RATS Ciencias Biológicas chemistry.chemical_compound PRENATAL STRESS Pregnancy Stress Physiological Corticosterone Internal medicine medicine Animals PCNA Chronic stress Rats Wistar GESTATION Cell Proliferation Dentate gyrus PROLIFERATION CENTRAL NERVOUS SYSTEM General Medicine Prenatal development Prolactin Medical Laboratory Technology medicine.anatomical_structure Endocrinology chemistry Prenatal stress Prenatal Exposure Delayed Effects Gestation Female CIENCIAS NATURALES Y EXACTAS |
Zdroj: | Biotechnic & Histochemistry. 90:146-151 |
ISSN: | 1473-7760 1052-0295 |
Popis: | The survival of developing embryos depends on the control and maintenance of homeostasis. Stress caused by chronic immobilization during pregnancy in rats may alter the normal development of the nervous system and increase susceptibility to psychiatric disorders. We investigated the effects of chronic stress on cell proliferation in the forebrains of embryos at 12 days of gestation, and in the hippocampus, dentate gyrus and cortex in embryos at 17 and 21 days of gestation. We examined serial sections of the embryonic brains of control and stressed rats at days 12, 17 and 21 of gestation. Brain sections were immunolabeled with anti-PCNA and stereological analysis was performed on 540 images. The results showed no statistical differences on days 12 and 17 of gestation in the proliferation area of the structures studied, whereas on day 21 of gestation, proliferation decreased in the cortex and dentate gyrus of embryos of the stressed group. These changes were related to decreased prolactin and increased corticosterone concentrations in the plasma. Fil: Giordana, Lucila. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Bozzo, Aida Andrea. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal; Argentina Fil: Cots, Debora Soledad. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Monedero Cobeta, i.. Universidad Autónoma de Madrid; España Fil: Rolando, Alicia Nelida. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal; Argentina Fil: Borghi, Damiana. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Díaz, Tomás. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Gauna, Hector Fernando. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; Argentina Fil: Romanini, María Cristina. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal; Argentina |
Databáze: | OpenAIRE |
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