The Colorful Palette of Neuroendocrine Neoplasms in the Genitourinary Tract
| Autor: | Levente Kuthi, Ibolya Laczó, Linda Varga, János Révész, Réka Kránicz, Boglárka Pósfai, Anikó Maráz |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Cancer Research Pathology medicine.medical_specialty medicine.medical_treatment Neuroendocrine tumors Adenocarcinoma Small-cell carcinoma Neuroendocrine differentiation 03 medical and health sciences 0302 clinical medicine medicine Humans Carcinoma Small Cell Chemotherapy Genitourinary system business.industry Large cell Cancer Prostatic Neoplasms General Medicine medicine.disease Kidney Neoplasms Radiation therapy Neuroendocrine Tumors 030104 developmental biology Oncology Urinary Bladder Neoplasms 030220 oncology & carcinogenesis Carcinoma Large Cell business |
| Zdroj: | Anticancer research. 38(6) |
| ISSN: | 1791-7530 |
| Popis: | Background Neuroendocrine neoplasms include a heterogeneous group of malignant tumors. Primary neuroendocrine tumors in the genitourinary tract are rare, comprising approximately 1-2% of genitourinary malignancies. Materials and methods An extensive search was performed for publications between 2000 and 2018 regarding neuroendocrine tumors of the genitourinary tract. Epidemiological, clinical, histopathological, prognostic and therapeutic data were evaluated. Results Neuroendocrine tumors of the kidneys are exceedingly rare, mostly well-differentiated. 0.5-1% of all primary bladder malignancies are small cell neuroendocrine carcinomas. Characteristically, prostatic adenocarcinoma with neuroendocrine differentiation occurs in androgen receptor-independent/castrate-resistant cancer. Small cell and large cell neuroendocrine carcinomas are the most aggressive tumors in each location. Conclusion Due to the rarity and poor prognosis of these tumors, proper pathological diagnosis and early therapy are important. Therapeutic guidelines are not available. Surgery, radiotherapy and/or chemotherapy are possible treatment options; somatostatin analogs are used as standard therapy in case of well-differentiated neuroendocrine tumors. |
| Databáze: | OpenAIRE |
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