A plasmocyte selective monoclonal antibody (B-B4) recognizes syndecan-1
| Autor: | Jean-Michel Dore, Patrick Laurent, Ren-Xiao Sun, Natalio Vita, Jacob Post, Bernard Klein, John Wijdenes, Florence Morard, Wim C. Vooijs, Claude Clement |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Syndecans
medicine.drug_class Blotting Western Palatine Tonsil Plasma Cells CD34 Monoclonal antibody Syndecan 1 Antigen Bone Marrow medicine Biomarkers Tumor Tumor Cells Cultured Humans Cloning Molecular Multiple myeloma Electrophoresis Agar Gel Blood Cells Membrane Glycoproteins biology Antibodies Monoclonal Hematology medicine.disease medicine.anatomical_structure Cell culture Immunology Cancer research biology.protein Proteoglycans Bone marrow Syndecan-1 Antibody Multiple Myeloma |
| Zdroj: | British journal of haematology. 94(2) |
| ISSN: | 0007-1048 |
| Popis: | We developed a new monoclonal antibody. B-B4, which specifically identifies human plasma cells. It strongly reacts with all multiple myeloma cell lines and with malignant plasma cells of all tumour samples of the multiple myeloma patients tested. B-B4 does not react with any peripheral blood, bone marrow or tonsil cells. Cloning of the B-B4 antigen reveals that the monoclonal antibody recognizes syndecan-1. It appears that the monoclonal antibody B-B4 is a suitable marker for human plasmocyte identification among haemopoietic cells and a useful probe for the diagnosis of haematological malignancies. Furthermore, this monoclonal antibody can be used for depletions prior to CD34 grafting. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text