The Clinical and Economic Impact of Measles-Mumps-Rubella Vaccinations to Prevent Measles Importations From US Pediatric Travelers Returning From Abroad

Autor: Audrey C Bangs, Paul Gastañaduy, Anne M Neilan, Amy Parker Fiebelkorn, Allison Taylor Walker, Sowmya R Rao, Edward T Ryan, Regina C LaRocque, Rochelle P Walensky, Emily P Hyle
Rok vydání: 2022
Předmět:
Zdroj: Journal of the Pediatric Infectious Diseases Society. 11:257-266
ISSN: 2048-7207
Popis: Background Pediatric international travelers account for nearly half of measles importations in the United States. Over one third of pediatric international travelers depart the United States without the recommended measles-mumps-rubella (MMR) vaccinations: 2 doses for travelers ≥12 months and 1 dose for travelers 6 to Methods We developed a model to compare 2 strategies among a simulated cohort of international travelers (6 months to Results Compared with no PHE, PHE would avert 57 measles cases at $9.2 million/QALY among infant travelers and 7 measles cases at $15.0 million/QALY among preschool-aged travelers. Clinical benefits of PHE would be greatest for infants but cost-effective only for travelers to destinations with higher risk for measles exposure (ie, ≥160 exposures/million travelers) or if more US-acquired cases resulted from an infected traveler, such as in communities with limited MMR coverage. Conclusions Pretravel MMR vaccination provides the greatest clinical benefit for infant travelers and can be cost-effective before travel to destinations with high risk for measles exposure or from communities with low MMR vaccination coverage.
Databáze: OpenAIRE
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