Host inflammasome defense mechanisms and bacterial pathogen evasion strategies
| Autor: | Sky W. Brubaker, Susan M. Brewer, Denise M. Monack |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Inflammasomes Immunology Biology Bacterial Physiological Phenomena 03 medical and health sciences 0302 clinical medicine Immune system Immunity medicine Animals Humans Immunology and Allergy Disease Resistance Immune Evasion Innate immune system Host cell cytosol Pattern recognition receptor Inflammasome Bacterial Infections Evasion (ethics) Immunity Innate 030104 developmental biology Multiprotein Complexes Host-Pathogen Interactions Disease Susceptibility Biomarkers Protein Binding Signal Transduction 030215 immunology medicine.drug |
| Zdroj: | Current Opinion in Immunology. 60:63-70 |
| ISSN: | 0952-7915 |
| Popis: | Inflammasomes are a formidable armada of intracellular pattern recognition receptors. They recognize determinants of infection, such as foreign entities or danger signals within the host cell cytosol, rapidly executing innate immune defenses and initiating adaptive immune responses. Although inflammasomes are implicated in many diseases, they are especially critical in host protection against intracellular bacterial pathogens. Given this role, it is not surprising that many pathogens have evolved effective strategies to evade inflammasome activation. In this review, we will provide a brief summary of inflammasome activation during infection with the intent of highlighting recent advances in the field. Additionally, we will review known bacterial evasion strategies and countermeasures that impact pathogenesis. |
| Databáze: | OpenAIRE |
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