Divergent splanchnic sympathetic efferent nerve pathways regulate interleukin‐10 and tumour necrosis factor‐α responses to endotoxaemia

Autor:	Michael J. McKinley, Davide Martelli, Pedro Trevizan‐Baú, Robin M. McAllen
Rok vydání:	2022
Předmět:	Lipopolysaccharides Sympathetic Nervous System Epinephrine Tumor Necrosis Factor-alpha Physiology Splanchnic Nerves Vagus Nerve Pentolinium Tartrate Endotoxemia Interleukin-10 Rats Propanolamines Reflex Animals Cytokines
Zdroj:	The Journal of Physiology. 600:4521-4536
ISSN:	1469-7793 0022-3751
DOI:	10.1113/jp283217
Popis:	The efferent branches of the splanchnic sympathetic nerves that enhance interleukin-10 (IL-10) and suppress tumour necrosis factor-α (TNF) levels in the reflex response to systemic immune challenge were investigated in anaesthetized, ventilated rats. Plasma levels of TNF and IL-10 were measured 90 min after intravenous lipopolysaccharide (LPS, 60 µg/kg). Splanchnic nerve section, ganglionic blockade with pentolinium tartrate or β
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0015194c9a35980b87b68a31a3d13248 https://doi.org/10.1113/jp283217 Zobrazit plný text záznamu Plný text