Supplementary Figure S1 from Mechanisms of Resistance to EGFR Inhibition Reveal Metabolic Vulnerabilities in Human GBM

Autor: Joanna J. Phillips, William A. Weiss, Monika E. Hegi, Albert Lai, William H. Yong, Theodore P. Nicolaides, C. David James, Joseph T.C. Shieh, Mitchel S. Berger, Andrew W. Bollen, Michael Prados, Linda M. Liau, Timothy F. Cloughesy, Erin F. Simonds, Kan V. Lu, Henry Gong, Anupam Kumar, Katharine Y. Chen, Jane R. Engler, Olle R. Lindberg, Andrew McKinney
Rok vydání: 2023
DOI: 10.1158/1535-7163.22506199
Popis: Supplementary Figure S1 shows increased invasion is specific to EGFR inhibition, increased ALDH1A1 expression is not specific to erlotinib but also occurs with AG1478 and lapatinib, and EGFR inhibition increases expression of several genes implicated in cell adhesion and motility.
Databáze: OpenAIRE