The effect of estriol on the cytology of urethra and vagina in postmenopausal women with genito-urinary symptoms
| Autor: | C.M.E. Kremer, M.C.G.J. van der Linden, E.C.M. Ooms, M.S. Brandhorst, G. Gerretsen, Wim H. Doesburg |
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| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Urinary incontinence Placebo Epithelium Vaginal disease Double-Blind Method Urethra Cytology Humans Medicine Aged Gynecology Estriol business.industry Estrogen Replacement Therapy Obstetrics and Gynecology Middle Aged Postmenopause Urinary Incontinence medicine.anatomical_structure Reproductive Medicine Estrogen Vagina Female Atrophy medicine.symptom business hormones hormone substitutes and hormone antagonists |
| Zdroj: | European Journal of Obstetrics & Gynecology and Reproductive Biology. 51:29-33 |
| ISSN: | 0301-2115 |
| DOI: | 10.1016/0028-2243(93)90187-h |
| Popis: | In a double-blind, randomised trial, 62 postmenopausal women with genito-urinary symptoms were treated with oestriol or matching placebo for 4 weeks. Estriol (Synapause-E3, Nourypharma Nederland) was given orally for 4 weeks in a single daily dose (8 mg/day first week, 4 mg/day second and third week, 2 mg/day fourth week). The influence of estriol on the vaginal and urethral epithelium was assessed by using the karyopycnotic index and the maturation value. As we expected, it was confirmed that estriol has a remarkably beneficial effect on the vaginal epithelium. This also applies to the epithelium of the urethra, although the effect is much less obvious. |
| Databáze: | OpenAIRE |
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