Association of the cholesteryl ester transfer protein Taq1 B2B2 genotype with higher high-density lipoprotein cholesterol concentrations and lower risk of coronary artery disease in a Tunisian population

Autor: Ali Bouslama, Jihène Rejeb, Ilyes Naffeti, Ibtihel Bel HadjMbarek, Essia Boughzala, Amira Boujelbene, R. Belkahla, Naoufel Nabli, Ahmed Ben Abdelaziz, Asma Omezzine, Nabila Ben Rejeb, Lamia Rebhi, Kaouther Kchok
Rok vydání: 2008
Předmět:
Male
medicine.medical_specialty
Tunisia
Apolipoprotein B
Genotype
Coronary Artery Disease
Polymorphisme Taq1B
Lower risk
Tunisie
Maladies coronariennes
Coronary artery disease
chemistry.chemical_compound
High-density lipoprotein
Sex Factors
High-density lipoprotein cholesterol
Protéine de transfert des esters de cholestérol
Internal medicine
Cholesterylester transfer protein
medicine
Humans
Prospective Studies
Lipoprotéine de haute densité
Allele frequency
Alleles
Aged
Polymorphism
Genetic
biology
Cholesterol
business.industry
Smoking
Coronary Stenosis
General Medicine
Odds ratio
Middle Aged
medicine.disease
Cholesteryl ester transfer protein
Taq1B polymorphism
Cholesterol Ester Transfer Proteins
Endocrinology
chemistry
biology.protein
lipids (amino acids
peptides
and proteins)
Female
Cardiology and Cardiovascular Medicine
business
Lipoproteins
HDL
Zdroj: Archives of cardiovascular diseases. 101(10)
ISSN: 1875-2136
Popis: Summary Background The role of cholesteryl ester transfer protein (CETP) in the development of atherosclerosis is undergoing debate. Aims In this prospective study, we sought to explore the role of the CETP Taq1B variant in coronary artery disease risk, and its association with plasma lipid and apolipoprotein concentrations. Methods DNA was extracted from 316 patients undergoing coronary angiography. The Taq1B polymorphism was genotyped using polymerase chain reaction–restriction fragment length polymorphism analysis. Lipid and apolipoprotein concentrations were measured by enzymatic and nephelometric assays. Results In our study population, the B2 allele frequency was 0.29. B2 allele carriers had a significantly higher high-density lipoprotein cholesterol (HDL-C) concentration than those with the B1B1 genotype (1.041 ± 0.294 versus 0.995 ± 0.277; p = 0.039). After adjusting for age, sex, smoking status, diabetes, hypertension and dyslipidaemia, the odds ratio (OR) for significant stenosis associated with the B2 allele was 0.82 (95% confidence interval (CI) 0.60–0.97; p = 0.039), suggesting that the B2 allele is associated with an 18% lower risk of significant stenosis. This protective effect seemed to be more significant in male nonsmokers (38% lower risk; OR 0.62, 95% CI 0.29–0.92; p = 0.029). No significant protective effects were observed in women or male smokers. Conclusion Our data suggest that the B2 allele is associated with higher concentrations of HDL-C, which confer a protective effect with regard to coronary atherosclerosis. This effect seems to be more significant in men than in women and in nonsmokers than in smokers.
Databáze: OpenAIRE
Externí odkaz: