Association of the cholesteryl ester transfer protein Taq1 B2B2 genotype with higher high-density lipoprotein cholesterol concentrations and lower risk of coronary artery disease in a Tunisian population
Autor: | Ali Bouslama, Jihène Rejeb, Ilyes Naffeti, Ibtihel Bel HadjMbarek, Essia Boughzala, Amira Boujelbene, R. Belkahla, Naoufel Nabli, Ahmed Ben Abdelaziz, Asma Omezzine, Nabila Ben Rejeb, Lamia Rebhi, Kaouther Kchok |
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Rok vydání: | 2008 |
Předmět: |
Male
medicine.medical_specialty Tunisia Apolipoprotein B Genotype Coronary Artery Disease Polymorphisme Taq1B Lower risk Tunisie Maladies coronariennes Coronary artery disease chemistry.chemical_compound High-density lipoprotein Sex Factors High-density lipoprotein cholesterol Protéine de transfert des esters de cholestérol Internal medicine Cholesterylester transfer protein medicine Humans Prospective Studies Lipoprotéine de haute densité Allele frequency Alleles Aged Polymorphism Genetic biology Cholesterol business.industry Smoking Coronary Stenosis General Medicine Odds ratio Middle Aged medicine.disease Cholesteryl ester transfer protein Taq1B polymorphism Cholesterol Ester Transfer Proteins Endocrinology chemistry biology.protein lipids (amino acids peptides and proteins) Female Cardiology and Cardiovascular Medicine business Lipoproteins HDL |
Zdroj: | Archives of cardiovascular diseases. 101(10) |
ISSN: | 1875-2136 |
Popis: | Summary Background The role of cholesteryl ester transfer protein (CETP) in the development of atherosclerosis is undergoing debate. Aims In this prospective study, we sought to explore the role of the CETP Taq1B variant in coronary artery disease risk, and its association with plasma lipid and apolipoprotein concentrations. Methods DNA was extracted from 316 patients undergoing coronary angiography. The Taq1B polymorphism was genotyped using polymerase chain reaction–restriction fragment length polymorphism analysis. Lipid and apolipoprotein concentrations were measured by enzymatic and nephelometric assays. Results In our study population, the B2 allele frequency was 0.29. B2 allele carriers had a significantly higher high-density lipoprotein cholesterol (HDL-C) concentration than those with the B1B1 genotype (1.041 ± 0.294 versus 0.995 ± 0.277; p = 0.039). After adjusting for age, sex, smoking status, diabetes, hypertension and dyslipidaemia, the odds ratio (OR) for significant stenosis associated with the B2 allele was 0.82 (95% confidence interval (CI) 0.60–0.97; p = 0.039), suggesting that the B2 allele is associated with an 18% lower risk of significant stenosis. This protective effect seemed to be more significant in male nonsmokers (38% lower risk; OR 0.62, 95% CI 0.29–0.92; p = 0.029). No significant protective effects were observed in women or male smokers. Conclusion Our data suggest that the B2 allele is associated with higher concentrations of HDL-C, which confer a protective effect with regard to coronary atherosclerosis. This effect seems to be more significant in men than in women and in nonsmokers than in smokers. |
Databáze: | OpenAIRE |
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