Tuberculin reactivity in adults after 50 years of universal bacille Calmette-Guerin vaccination in Taiwan
| Autor: | H.J. Chang, Y.P. Yeh, Tony Hsiu Hsi Chen, J. Suo, Shu-Hui Chang, Dih Ling Luh |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Tuberculosis Time Factors Adolescent Population Taiwan Tuberculin Age Distribution Risk Factors medicine Humans Sex Distribution education Child Aged Tuberculina education.field_of_study biology business.industry Tuberculin Test Risk of infection Public Health Environmental and Occupational Health General Medicine Middle Aged biology.organism_classification medicine.disease Vaccination Infectious Diseases Immunology Tropical medicine BCG Vaccine Parasitology Female business BCG vaccine |
| Zdroj: | Transactions of the Royal Society of Tropical Medicine and Hygiene. 99(7) |
| ISSN: | 0035-9203 |
| Popis: | We aimed to assess whether tuberculin reactivity in adults is affected by bacille Calmette-Guerin (BCG) vaccination after 50 years of universal BCG vaccination with 80-95% coverage. A community-based study on tuberculin reactivity in 619 participants was conducted in February 2000 in Keelung city, Taiwan. Information on BCG vaccination policies and annual risk of infection (ARI) in the underlying population was extracted from consecutive national prevalence surveys relating to the period 1952-1997. Compared with the expected ARI estimate, the standardized morbidity ratio of positive tuberculin response for vaccination in infancy was 2.2 (95% CI 0.3-15.5) for those aged10 years. The corresponding figures for older age groups ranged from 3.6 (95% CI 2.2-5.9) for those aged 10-12 years to 0.7 (95% CI 0.5-0.9) for those aged 57-67 years. This suggests that the effect of BCG vaccination on positive tuberculin response in adults aged30 years is probably negligible irrespective of age at vaccination or revaccination and that the tuberculin skin test can be used to diagnose TB in control programmes in countries with moderate or high incidence of TB. |
| Databáze: | OpenAIRE |
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