The sarcoma, breast cancer, lung cancer, and adrenocortical carcinoma syndrome revisited. Childhood cancer
| Autor: | Jane F. Lynch, Patrick Bogard, David Allan Katz, Henry T. Lynch |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Oncology
Male medicine.medical_specialty Lung Neoplasms Breast Neoplasms Neoplasms Multiple Primary Breast cancer Internal medicine Epidemiology of cancer Rhabdomyosarcoma medicine Carcinoma Adrenocortical carcinoma Humans Lung cancer Child business.industry Brain Neoplasms Cancer Sarcoma Glioma Syndrome medicine.disease Adrenal Cortex Neoplasms Pedigree Child Preschool Female business |
| Zdroj: | American journal of diseases of children (1960). 139(2) |
| ISSN: | 0002-922X |
| Popis: | • We studied two children who had rhabdomyosarcoma and glioblastoma and who were from a family with a hereditary cancer syndrome that was characterized by sarcoma, breast cancer, brain tumors, lung cancer, laryngeal carcinoma, leukemia, and adrenocortical carcinoma. The deleterious genotype has now been expressed through the fourth generation of this large kindred. The pedigree emphasizes the need for an extended history of several generations to arrive at a hereditary-syndrome diagnosis. A limited pedigree may result in nonappreciation of the genetic component. The pedigree illustrates that, in certain circumstances, the highly specific varieties of cancer may occur in children before it is expressed in the parent who carries the putative gene. Pediatricians, in evaluating the causes of childhood cancer, must be cognizant of cancer among adult relatives, since this recognition may aid in the diagnosis of those hereditary cancer syndromes that are characterized by cancer occurrence in children as well as adults. ( AJDC 1985;139:134-136) |
| Databáze: | OpenAIRE |
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