HCV NS5B polymerase inhibitors 2: Synthesis and in vitro activity of (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives

Autor:	Antitsa Dimitrova Stoycheva, Leonid Beigelman, Karl Kossen, P. T. Ravi Rajagopalan, Donald Ruhrmund, Guangyi Wang, Brunella Felicetti, Colin H. MacKinnon, Scott D. Seiwert, Christian A.G.N. Montalbetti, Brad O. Buckman, Debasis Das, Dorian Leo Schönfeld, Huoxing Lei, Thomas Stephen Coulter, John Barker, Jian Hong, Shawn Misialek, Lisa Hooi, Sarah E. Bailey, Xinjie Gai, Wang Xiaofang, Robert K. Y. Cheng, Richard John Mears
Rok vydání:	2009
Předmět:	Azoles Magnetic Resonance Spectroscopy Pyrimidine Pyridines Stereochemistry Chemistry Pharmaceutical viruses Clinical Biochemistry Pharmaceutical Science Hepacivirus In Vitro Techniques Viral Nonstructural Proteins Benzothiadiazines Antiviral Agents Biochemistry Chemical synthesis Inhibitory Concentration 50 Structure-Activity Relationship chemistry.chemical_compound Drug Discovery Pyridine Animals Structure–activity relationship Enzyme Inhibitors Molecular Biology Molecular Structure biology Bicyclic molecule Organic Chemistry virus diseases biochemical phenomena metabolism and nutrition Hepatitis C digestive system diseases Pyrimidines Models Chemical chemistry Benzothiadiazine Enzyme inhibitor Drug Design biology.protein Lactam Molecular Medicine
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 19:4480-4483
ISSN:	0960-894X
DOI:	10.1016/j.bmcl.2009.05.022
Popis:	(1,1-Dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives have been investigated as potential anti-HCV drugs. Their synthesis, HCV NS5B polymerase inhibition, and replicon activity are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::000ef0a9262fe818849b255d0368b7bd https://doi.org/10.1016/j.bmcl.2009.05.022 Zobrazit plný text záznamu Full Text from ScienceDirect