Restoration of spinal bone in osteoporotic men by treatment with human parathyroid hormone (1-34) and 1,25-dihydroxyvitamin D
| Autor: | Daniel I. Rosenthal, Samuel H. Doppelt, David M. Slovik, Robert M. Neer, Margaret Daly, John T. Potts, Julie A. Campbell |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Bone Regeneration Endocrinology Diabetes and Metabolism Parathyroid hormone chemistry.chemical_element Calcium Intestinal absorption Bone resorption Phosphorus metabolism Calcitriol Teriparatide Internal medicine medicine Humans Orthopedics and Sports Medicine Calcium metabolism Bone mineral business.industry Phosphorus Middle Aged Peptide Fragments Spine Endocrinology chemistry Parathyroid Hormone Osteoporosis Drug Therapy Combination business Densitometry medicine.drug |
| Zdroj: | Journal of Bone and Mineral Research. 1:377-381 |
| ISSN: | 0884-0431 |
| DOI: | 10.1002/jbmr.5650010411 |
| Popis: | Daily subcutaneous injection of a synthetic human parathyroid hormone fragment, combined with daily ingestion of 1,25(OH)2 vitamin D, significantly increased trabecular bone density in the spine (p less than .01), and improved intestinal calcium and phosphorus absorption and total body retention of dietary calcium and phosphorus in middle-aged men with idiopathic osteoporosis. The increases in spinal bone mineral were marked and progressive during a year of treatment. These results indicate that increasing intestinal absorption of dietary calcium while simultaneously stimulating new bone formation with small doses of parathyroid hormone can restore spinal bone in osteoporotic men. |
| Databáze: | OpenAIRE |
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