VEGF promotes tumorigenesis and angiogenesis of human glioblastoma stem cells
| Autor: | Masafumi Onodera, Toru Iwama, Akihito Inagaki, Akira Hara, Hidekazu Maruyama, Akio Soeda, Takahiro Kunisada, Naoki Oka, Hideki Mori |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Vascular Endothelial Growth Factor A
Angiogenesis Biophysics Mice SCID Tumor initiation Biology medicine.disease_cause Biochemistry Mice chemistry.chemical_compound Mice Inbred NOD Cancer stem cell Cell Line Tumor medicine Animals Humans Molecular Biology Cell Proliferation Neovascularization Pathologic Neurogenesis Cell Biology Xenograft Model Antitumor Assays Neural stem cell Vascular endothelial growth factor chemistry Immunology Disease Progression Neoplastic Stem Cells Cancer research Stem cell Glioblastoma Carcinogenesis |
| Zdroj: | Biochemical and Biophysical Research Communications. 360:553-559 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/j.bbrc.2007.06.094 |
| Popis: | There is increasing evidence for the presence of cancer stem cells (CSCs) in malignant brain tumors, and these CSCs may play a pivotal role in tumor initiation, growth, and recurrence. Vascular endothelial growth factor (VEGF) promotes the proliferation of vascular endothelial cells (VECs) and the neurogenesis of neural stem cells. Using CSCs derived from human glioblastomas and a retrovirus expressing VEGF, we examined the effects of VEGF on the properties of CSCs in vitro and in vivo. Although VEGF did not affect the property of CSCs in vitro, the injection of mouse brains with VEGF-expressing CSCs led to the massive expansion of vascular-rich GBM, tumor-associated hemorrhage, and high morbidity, suggesting that VEGF promoted tumorigenesis via angiogenesis. These results revealed that VEGF induced the proliferation of VEC in the vascular-rich tumor environment, the so-called stem cell niche. |
| Databáze: | OpenAIRE |
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