Protein-Activatable Diarylethene Monomer as a Smart Trigger of Noninvasive Control Over Reversible Generation of Singlet Oxygen: A Facile, Switchable, Theranostic Strategy for Photodynamic-Immunotherapy
Autor: | Jin Cao, Jing Zhao, Xing-Jie Liang, Juyoung Yoon, Yuanli Luo, Hong Bo Cheng, Zhigang Wang, Hao Li, Jin Yong Lee, K.M.K. Swamy, Bin Qiao |
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Rok vydání: | 2021 |
Předmět: |
Singlet Oxygen
Singlet oxygen medicine.medical_treatment Supramolecular chemistry Nanotechnology Photodynamic therapy General Chemistry Hydrocarbons Aromatic Biochemistry Porphyrin Catalysis chemistry.chemical_compound Photochromism Colloid and Surface Chemistry Photochemotherapy Diarylethene chemistry Albumins Cell Line Tumor medicine Humans Moiety Photosensitizer Immunotherapy |
Zdroj: | Journal of the American Chemical Society. 143:2413-2422 |
ISSN: | 1520-5126 0002-7863 |
Popis: | The development of activatable photosensitizers to allow for the reversible control of singlet oxygen (1O2) production for photodynamic therapy (PDT) faces great challenges. Fortunately, the flourishing field of supramolecular biotechnology provides more effective strategies for activatable PDT systems. Here, we developed a new reversible PDT on a switch that controls the 1O2 generation of self-assembled albumin nanotheranostics in vitro and in vivo. A new molecular design principle of aggregation-induced self-quenching photochromism and albumin on-photoswitching was demonstrated using a new asymmetric, synthetic diarylethene moiety DIA. The photosensitizer porphyrin and DIA were incorporated as building blocks in a glutaraldehyde-induced covalent albumin cross-linking nanoplatform, HSA-DIA-porphyrin nanoparticles (NPs). More importantly, the excellent photoswitching property of DIA enables the resultant nanoplatform to act as a facile, switchable strategy for photodynamic-immunotherapy. |
Databáze: | OpenAIRE |
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