Posterior fossa involvement in a recurrent gliosarcoma
| Autor: | Devendra K Tyagi, Sridhar Epari, Srikant Balasubramaniam, Hemant V Sawant |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
gliosarcoma Gliosarcoma medicine.medical_treatment Case Report 030218 nuclear medicine & medical imaging Temporal lobe lcsh:RC321-571 03 medical and health sciences Lethargy 0302 clinical medicine Adjuvant therapy medicine lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry medicine.diagnostic_test posterior fossa tumor business.industry General Neuroscience Magnetic resonance imaging medicine.disease recurrence in posterior fossa Surgery Radiation therapy Recurrent Gliosarcoma Histopathology Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neurosciences in Rural Practice, Vol 03, Iss 01, Pp 60-64 (2012) Journal of Neurosciences in Rural Practice |
| ISSN: | 0976-3155 0976-3147 |
| Popis: | Gliosarcoma (GSM) is a WHO grade 4 tumor and a variant of glioblastoma multiforme with predilection for the temporal lobe. We record, perhaps the first case in literature, of a temporal lobe GSM with recurrence involving the posterior fossa. A 50-year-old man presented to us with headache, vomiting, and lethargy of relatively recent onset. Magnetic resonance imaging revealed a well-circumscribed lesion in the left temporal lobe for which left temporal craniotomy with radical excision of the tumor was performed. Histopathology was suggestive of GSM. He presented to us within a month of the first surgery with a large recurrence involving the temporal lobe. He underwent a second surgery with radical excision of the tumor. Histopathology was confirmatory of GSM. He was administered concomitant chemotherapy and radiotherapy. Within a fortnight of starting adjuvant therapy, the bone flap started bulging and a repeat computed tomography scan revealed a large recurrence extending into the posterior fossa. The patient′s relatives refused consent for third surgery and he finally succumbed on postoperative day 21. GSMs are aggressive tumors that have a temporal lobe predilection, but they may present anywhere in the brain. Detailed studies on larger cohort of cases are needed to understand the true nature of these biphasic tumors. |
| Databáze: | OpenAIRE |
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