Thyroid status in premenopausal and postmenopausal women - A biochemical study on insulin resistance in non obese, overweight and obese type 2 diabetics
| Autor: | A R Srinivasan, Niranjan G, Rajendran Jayanthi |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
medicine.medical_specialty Endocrinology Diabetes and Metabolism Thyrotropin 030209 endocrinology & metabolism Type 2 diabetes 030204 cardiovascular system & hematology Overweight 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Insulin resistance Diabetes mellitus Internal medicine Internal Medicine medicine Humans Obesity Aged medicine.diagnostic_test Anthropometry business.industry General Medicine Middle Aged medicine.disease Menopause Postmenopause Thyroxine Endocrinology chemistry Diabetes Mellitus Type 2 Premenopause Female Glycated hemoglobin medicine.symptom Insulin Resistance Lipid profile business |
| Zdroj: | Diabetesmetabolic syndrome. 12(6) |
| ISSN: | 1878-0334 |
| Popis: | Insulin resistance with altered thyroid status in women is observed in type 2 diabetics and varies with advancing age and estrogen profile. We compared thyroid status between premenopausal and postmenopausal women in obese, non obese and overweight type 2 diabetes.We included 301type 2 diabetics who were segregated into premenopausal (n = 100) 33.2% and postmenopausal (n = 201) 66.8% among three sub groups (Non obese, overweight and Obese).Anthropometry, fasting blood glucose, lipid profile, glycated hemoglobin, homeostasis model assessment of insulin resistance, liver function tests, Free T4, T3, TSH, ZnNon obese type 2 diabetics were segregated into two groups n = 21 (29.2%)- premenopausal with mean age of 41.48 ± 4.30 and n = 51 (70.8%) - post menopausal with mean age of 58.49 ± 7.32 There were significant differences in WHR, HbA1c, HDL with p 0.05 and ALP with p 0.01; Overweight type 2 diabetics n = 55 (37.9%) -premenopausal with mean age of 41.96 ± 3.80 and n = 90 (62.1%)- post menopausal with mean age of 57.80 ± 7.20. There were significant differences in Urea, Zinc, Total protein, Albumin with p 0.05 and T4, TSH with p 0.01. Obese Type 2 diabetics n = 24 (28.6%) -premenopausal with mean age of 42.00 ± 4.30 and n = 60 (71.4%) -post menopausal with mean age of 57.80 ± 7.20. There were significant differences in Urea, Magnesium, Triacylglycerols, and VLDL with p 0.05, Insulin and HOMA-IR with p 0.01.Anthropometry specified classification of type 2 diabetics in pre and postmenopausal women reflects thyroid status. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect