Evaluation of Dynamic Contrast-Enhanced MRI Measures of Lung Congestion and Endothelial Permeability in Heart Failure: A Prospective Method Validation Study

Autor:	Joseph Cheriyan, Alexandra Roberts, Caleb Roberts, Martin J. Graves, Ilse Patterson, Rhys A. Slough, Rosemary Schroyer, Disala Fernando, Subramanya Kumar, Sarah Lee, Geoffrey J.M. Parker, Lea Sarov‐Blat, Carmel McEniery, Jessica Middlemiss, Dennis Sprecher, Robert L. Janiczek
Rok vydání:	2022
Předmět:	Heart Failure Contrast Media Humans Radiology Nuclear Medicine and imaging Lung Magnetic Resonance Imaging Permeability
Zdroj:	Journal of magnetic resonance imaging : JMRI. 56(2)
ISSN:	1522-2586
Popis:	Methods for accurate quantification of lung fluid in heart failure (HF) are needed. Dynamic contrast-enhanced (DCE)-MRI may be an appropriate modality.DCE-MRI evaluation of fraction of fluid volume in the interstitial lung space (vProspective, single-center method validation.Seventeen evaluable healthy volunteers (HVs), 12 participants with HF, and 3 with acute decompensated HF (ADHF).TThree whole-chest scans were acquired: baseline (Session 1), 1-week later (Session 2), following exercise (Session 3). Extended Tofts model quantified vThis was constructed as an experimental medicine study.KThere was no significant difference in mean KWhile no differences were detected in K2 TECHNICAL EFFICACY STAGE: 2.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0009b8f5b50c947739e38068e17c17e4 https://pubmed.ncbi.nlm.nih.gov/35332601 Zobrazit plný text záznamu Plný text