Brief report. Sexually-transmitted disease (STD) markers in multitransfused children in relation to human immunodeficiency virus type-1 (HIV-1) infection: impact of STD markers in blood donors
| Autor: | Kumari S, Aggarwal Rk, Shampa Sen, Charu Prakash, Chattopadhya D |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Male
Sexually transmitted disease HBsAg Blood transfusion medicine.medical_treatment Population Sexually Transmitted Diseases India Blood Donors Enzyme-Linked Immunosorbent Assay HIV Infections medicine.disease_cause Serology Acquired immunodeficiency syndrome (AIDS) HIV Seronegativity Humans Medicine Blood Transfusion Treponema pallidum Child education Retrospective Studies Hepatitis B virus education.field_of_study business.industry Transfusion Reaction virus diseases medicine.disease Virology Infectious Diseases Pediatrics Perinatology and Child Health Immunology HIV-1 business Viral hepatitis Biomarkers |
| Zdroj: | Journal of Tropical Pediatrics. 43:178-181 |
| ISSN: | 1465-3664 0142-6338 |
| DOI: | 10.1093/tropej/43.3.178 |
| Popis: | Association of serological markers for various sexually transmitted diseases (STDs) with Human Immunodeficiency Virus type 1 (HIV-1) infection among heterosexually promiscuous blood donors is well recognized. However, possibility of similar association among children receiving transfusion from these donors has not been adequately explored. Study on the association of some STD markers with HIV-1 infection in multitransfused (MT) children showed that both HIV-1 positive and HIV-1 negative groups of children had significantly higher prevalence of hepatitis B virus (HBV) markers, i.e. HBsAg (23 and 30 per cent), anti-HBs (46 and 57 per cent), anti-HBc (18 and 23 per cent), antibodies to cytomegalovirus of IgM class (36 and 37 per cent) and IgG class (72.7 and 70 per cent), IgG antibodies to Herpes Simplex Virus type-2 (23 and 23 per cent) compared to control group. However, seropositivity for HIV-1 infection could not be attributed as a risk factor for any of these markers in the group of MT children. On the contrary, significant association of anti HBc, anti HCV, CMV IgG and antitreponemal antibody with HIV-1 infection could be recorded in the group of blood donors. It appeared that due to low prevalence of HIV-1 infection among blood donors in India, both HIV-1 positive and HIV-1 negative groups of MT children received transfusion from HIV negative donors predominantly resulting in a comparable prevalence of STD markers in both the groups of MT children due to cumulative effect of transfusion from HIV-1 negative donors. |
| Databáze: | OpenAIRE |
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