Growth Assessment of Diabetic Rat Fetuses under the Influence of Insulin and Melatonin: a Morphologic Study
| Autor: | Nermine Nosseir, Shoair Mi, Abdel Halim Salem, El Badawi Mg, Raouf Fadel |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Placenta medicine.medical_treatment Pregnancy in Diabetics Weight Gain Crown-Rump Length Diabetes Mellitus Experimental Fetal Macrosomia Fetal Development Rats Sprague-Dawley Melatonin chemistry.chemical_compound Pregnancy Diabetes mellitus Internal medicine Alloxan Fetal macrosomia Animals Insulin Medicine Ecology Evolution Behavior and Systematics Crown-rump length Fetus business.industry General Medicine medicine.disease Rats Endocrinology chemistry Anthropology embryonic structures Gestation Female Animal Science and Zoology business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Anthropologischer Anzeiger. 68:129-138 |
| ISSN: | 0003-5548 |
| DOI: | 10.1127/0003-5548/2011/0093 |
| Popis: | Hyperglycemia-induced oxidative stress makes an important contribution to the etiology of diabetic teratogenicity namely fetal growth and congenital dysmorphogenesis. The aim of this study is to evaluate the protective roles of melatonin and insulin against diabetic's embryolethality and teratogenicity. Diabetes was induced to virgin Sprague Dawley albino rats by a single peritoneal injection of alloxan. Thirty pregnant rats were divided equally into 5 groups: 1) Control 2) Diabetic 3) Diabetic insulin 4) Diabetic melatonin 5) Diabetic melatonin-insulin. Insulin and melatonin were administered daily throughout the whole gestational period. Fetuses were collected on day 20 of gestation and were examined for malformations and growth disorders. A significant increase in fetal growth parameters (Macrosomia) were noticed in the diabetic group compared to the control. Melatonin prevents the appearance of soft tissue anomalies, but it leads to fetal growth restriction of diabetic rats (Microsomia). No significant changes were noticed in fetal growth parameters in diabetic insulin or in diabetic melatonin-insulin groups compared to the control. Congenital anomalies were not seen in diabetic insulin and in diabetic melatonin-insulin groups while the rate of resorption was reduced in both groups when compared to the diabetic group. In conclusion, co-administration of melatonin with insulin leads to a slight non significant improvement of the protective role of insulin against diabetic embryolethality, teratogenicity and fetal growth changes. |
| Databáze: | OpenAIRE |
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