Utility of genetic and non-genetic risk factors in predicting coronary heart disease in Singaporean Chinese

Autor:	Jianjun Liu, Rob M. van Dam, Yechiel Friedlander, Rajkumar Dorajoo, Chiea Chuen Khor, Yi Han, Yik Ying Teo, Chew-Kiat Heng, Agus Salim, Xu Wang, Daniel Yt Goh, Jian-Min Yuan, Woon-Puay Koh, Xuling Chang
Rok vydání:	2016
Předmět:	Male China medicine.medical_specialty Pathology Epidemiology Coronary Disease Single-nucleotide polymorphism Genome-wide association study 030204 cardiovascular system & hematology Polymorphism Single Nucleotide Risk Assessment 03 medical and health sciences 0302 clinical medicine Asian People Singapore chinese Risk Factors Internal medicine medicine Humans Genetic Predisposition to Disease 030212 general & internal medicine Genetic risk Aged Genetic association Singapore Framingham Risk Score biology business.industry Incidence C-reactive protein Middle Aged Prognosis Health Surveys Coronary heart disease C-Reactive Protein Phenotype Case-Control Studies Creatinine biology.protein Female Cardiology and Cardiovascular Medicine business Biomarkers
Zdroj:	European Journal of Preventive Cardiology. 24:153-160
ISSN:	2047-4881 2047-4873
Popis:	BackgroundAlthough numerous phenotype based equations for predicting risk of ‘hard’ coronary heart disease are available, data on the utility of genetic information for such risk prediction is lacking in Chinese populations.DesignCase–control study nested within the Singapore Chinese Health Study.MethodsA total of 1306 subjects comprising 836 men (267 incident cases and 569 controls) and 470 women (128 incident cases and 342 controls) were included. A Genetic Risk Score comprising 156 single nucleotide polymorphisms that have been robustly associated with coronary heart disease or its risk factors (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::000458ed1caa975a9a59fea1b5ebb932 https://doi.org/10.1177/2047487316676609 Zobrazit plný text záznamu