Elevated High Sensitivity C-Reactive Protein Is Associated with Type 2 Diabetes Mellitus: The Persian Gulf Healthy Heart Study
| Autor: | Fatemeh Azizi, Zahra Sanjdideh, Saeideh Beigi, Majid Assadi, Iraj Nabipour, Seyed Mojtaba Jafari, Katayoun Vahdat |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Population Iran Endocrinology Risk Factors Internal medicine Diabetes mellitus medicine Humans education education.field_of_study biology business.industry C-reactive protein Type 2 Diabetes Mellitus Odds ratio medicine.disease Obesity C-Reactive Protein Cross-Sectional Studies Diabetes Mellitus Type 2 Cardiovascular Diseases biology.protein Female business Body mass index Cohort study |
| Zdroj: | Endocrine Journal. 55:717-722 |
| ISSN: | 1348-4540 0918-8959 |
| Popis: | Previous studies have suggested that low-grade systemic inflammation is involved in the pathogenesis of type 2 diabetes mellitus. However, limited information is available about the relationship of diabetes mellitus and inflammation in Asia. We examined the association between high-sensitivity C-reactive protein (CRP) levels and diabetes in a general Iranian population. In an ancillary study to the Persian Gulf Healthy Heart Study, a cohort study of men and women aged ≥25 years, a random sample of 1754 (49.2 percent males, 50.8 percent females) subjects were evaluated. High sensitivity C-reactive protein was measured by enzyme-linked immunosorbent assay. Elevated serum CRP was defined as more than 3.0 mg/l. The diabetes classification was based on the criteria of the American Diabetes Association. A total of 8.6 percent of the subjects (8.0 percent of males & 9.1 percent of females; p>0.05) had type 2 diabetes mellitus. Geometric mean of CRP was 1.94 mg/l (3.80 SD) in the studied population. The subjects with diabetes had a higher geometric mean of CRP levels than the subjects with no diabetes [3.67 (SD 3.71) versus 1.85 (3.83) respectively; p |
| Databáze: | OpenAIRE |
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