Does autoimmune vitiligo protect against COVID-19 disease?
Autor: | Albert Wolkerstorfer, Rosalie M. Luiten, Marcel W. Bekkenk, Markus Böhm, Nicoline F. Post |
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Přispěvatelé: | Dermatology, AII - Inflammatory diseases |
Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
vitiligo medicine.medical_treatment Hypothesis Letter Dermatology Disease Vitiligo medicine.disease_cause Biochemistry Autoimmune Diseases Autoimmunity 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Immune system COVID‐19 medicine Humans Genetic Predisposition to Disease coronavirus SARS-CoV-2 Molecular Biology Disease burden Innate immune system SARS-CoV-2 business.industry autoimmunity COVID-19 Protective Factors Acquired immune system medicine.disease Immunity Innate 030104 developmental biology Cytokine coronavirus SARS‐CoV‐2 inflammation Immunology Cytokine Release Syndrome business |
Zdroj: | Experimental dermatology, 30(9), 1254-1257. Wiley-Blackwell Experimental Dermatology |
ISSN: | 0906-6705 |
Popis: | The SARS‐CoV‐2 pandemic has evolved to a global health problem with a dramatic morbidity and mortality rate impacting our daily life and those of many patients. While there is evidence that some diseases are associated with an increased risk for development of a more severe course of COVID‐19, little is known on protective conditions. Importantly, clearance of viral infection and protection against disease manifestation crucially depends on functional innate and adaptive immunity and the interferon signalling axis. Here, we hypothesize that patients with non‐segmental vitiligo (NSV), an autoimmune skin (and mucosal) disorder, may clear SARS‐CoV‐2 infection more efficiently and have a lower risk of COVID‐19 development. Conversely, in case of COVID‐19 development, vitiligo autoimmunity may influence the cytokine storm‐related disease burden. In addition, immune activation during SARS‐CoV‐2 infection or COVID‐19 disease might increase vitiligo disease activity. Our hypothesis is based on the shift of the immune system in NSV towards adaptive type 1 (IFNγ and CD8 T cells) and innate immune responses. Identified susceptibility genes of NSV patients may further confer increased antiviral activity. To validate our hypothesis, we suggest an international consortium to perform a retrospective data registry and patient‐reported study on a large number of NSV patients worldwide during the COVID‐19 pandemic. |
Databáze: | OpenAIRE |
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