Spirulina platensis and its ingredient biopterin glucoside improved insulin sensitivity in non-alcoholic steatohepatitis model
| Autor: | Yasumasa Kodo, Mitsumasa Mankura, Hiroshi Toyoda, Hideaki Kabuto, Fusako Takayama, Yuri Fujihara, Shin Ichi Miyoshi, Ritsuko Watanabe |
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| Rok vydání: | 2021 |
| Předmět: |
Spirulina (genus)
Nutrition and Dietetics biology Clinical Biochemistry Medicine (miscellaneous) Biopterin Pharmacology biology.organism_classification medicine.disease_cause medicine.disease chemistry.chemical_compound Ingredient Glucoside chemistry Phycocyanin medicine Steatohepatitis Arthrospira Oxidative stress |
| Zdroj: | Journal of Clinical Biochemistry and Nutrition. 69:151-157 |
| ISSN: | 1880-5086 0912-0009 |
| DOI: | 10.3164/jcbn.20-201 |
| Popis: | Non-alcoholic steatohepatitis is the chronic liver disease leading to cirrhosis and cancer and its prevalence is increasing. Some agents are under clinical trials for non-alcoholic steatohepatitis treatment. We previously reported Spirulina (Arthrospira) platensis effectively prevented non-alcoholic steatohepatitis progression in our model rats. The contribution of phycocyanin, an ingredient of Spirulina (Arthrospira) platensis, was limited. We, therefore, have looked for more active components of Spirulina (Arthrospira) platensis. In this study, we pursued the effect of biopterin glucoside, another bioactive ingredient of Spirulina (Arthrospira) platensis. We found Spirulina (Arthrospira) platensis and biopterin glucoside oral administrations effectively alleviated oxidative stress, inflammation and insulin signal failure, and prevented fibroblast growth factor 21 gene overexpression in non-alcoholic steatohepatitis rat livers. We concluded biopterin glucoside is a major component of Spirulina (Arthrospira) platensis action. |
| Databáze: | OpenAIRE |
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