Synthesis of sulfonimide-based dendrimers and dendrons possessing mixed 1 → 2 and 1 → 4 branching motifs
| Autor: | Julia Bondareva, Mykola V. Kolotylo, Vladimir V. Rozhkov, Oleg Lukin, V. M. Holovatiuk |
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| Rok vydání: | 2019 |
| Předmět: |
Sulfonyl
chemistry.chemical_classification 010405 organic chemistry Organic Chemistry 010402 general chemistry Branching (polymer chemistry) 01 natural sciences Biochemistry Chloride Sulfonyl chloride 0104 chemical sciences chemistry.chemical_compound Aniline chemistry Phenylene Dendrimer Drug Discovery Polymer chemistry medicine medicine.drug |
| Zdroj: | Tetrahedron Letters. 60:352-354 |
| ISSN: | 0040-4039 |
| Popis: | The synthesis of dendrimers and a chlorosulfo-dendron possessing a unique combination of 1 → 2 and 1 → 4 branching types is described. The procedure consists of a two-step preparation of 3,5-dinitrobenzene-1-sulfonyl chloride, which was used for the persulfonylation of p-toluidine and 4-(benzylthio)aniline. The obtained tetranitro compounds were reduced to the corresponding tetraamines. The latter were decorated with eight 4-toluene sulfonyl groups each to furnish the corresponding dendrimers. Oxidation of the dendrimer possessing a 4-(benzylthio)phenylene core with N-chlorosuccinimide resulted in the formation of a dendron with a sulfonyl chloride functionality at the focal point. |
| Databáze: | OpenAIRE |
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