Hepatitis B Virus DNA in Liver Tissue and Risk for Hepatocarcinogenesis in Patients with Hepatitis C Virus-Related Chronic Liver Disease
| Autor: | Hiromasa Ryuko, Mikako Obika, Ryo Terada, Shin Ichi Fujioka, Norio Koide, Toshiyuki Shinji, Aye Aye Lwin, Hidenori Shiraha |
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| Rok vydání: | 2008 |
| Předmět: |
Hepatitis B virus
Hepatitis B virus DNA polymerase business.industry viruses Hepatitis C virus food and beverages virus diseases Hepatitis C Hepatitis B medicine.disease Chronic liver disease medicine.disease_cause Virology digestive system diseases Infectious Diseases Hepatocellular carcinoma medicine Carcinoma business |
| Zdroj: | Intervirology. 51:59-68 |
| ISSN: | 1423-0100 0300-5526 |
| DOI: | 10.1159/000121363 |
| Popis: | Aims: To prospectively study whether occult hepatitis B virus (HBV) infection can promote the development of hepatocellular carcinoma (HCC) in patients with hepatitis C virus (HCV)-related chronic liver disease. In addition, to evaluate the difference among HBV DNA-negative patients and patients with high and low HBV copy numbers. Methods: A total of 167 patients with HCV-related chronic liver disease without HBV surface antigen (HBsAg) were studied. HBV DNA in liver tissue was determined using polymerase chain reaction (PCR). Results: HBV DNA was detected in 9 of 167 patients (5.4%) by single PCR and in 25 patients (15.0%) by nested PCR. HCC developed in 12 of 167 patients (7.2%). Ten of 142 HBV DNA-negative patients (7.0%) and 2 of 9 patients with a high HBV copy number (22.2%) developed HCC, whereas none of 16 patients with a low HBV copy number developed HCC. The incidence rate of HCC in patients with a high HBV copy number was significantly higher than in HBV DNA-negative patients and patients with low HBV copy number. Conclusion: A high amount of HBV DNA in liver tissue of HBsAg-negative patients with HCV-related liver disease might be associated with HCC development. |
| Databáze: | OpenAIRE |
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