Analysis of recurrence after the resection of pancreatic neuroendocrine tumors
| Autor: | Konstantinos Chouliaras, Edward A. Levine, Perry Shen, Naeem A. Newman, Gary N. Mann, Katrina R. Swett, Mrinal Shukla, Jonathan G. Sham |
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| Rok vydání: | 2018 |
| Předmět: |
Surgical resection
Chemotherapy medicine.medical_specialty Multivariate analysis business.industry medicine.medical_treatment General Medicine Neuroendocrine tumors medicine.disease Gastroenterology Resection 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Internal medicine Chart review Overall survival medicine 030211 gastroenterology & hepatology Surgery business Lymph node |
| Zdroj: | Journal of Surgical Oncology. 118:416-421 |
| ISSN: | 0022-4790 |
| Popis: | BACKGROUND AND OBJECTIVES Outcomes after recurrence of resected pancreatic neuroendocrine tumors (PNETs) are not well described. We aim to assess the rate and sites of recurrence, and its effect on clinical outcomes. METHODS Retrospective chart review of patients (n = 83) who underwent surgical resection of PNETs at 2 institutions. Patients were treated from September 2002 to July 2010. RESULTS There were 13 (16%) recurrences. The most common site of recurrence was the liver (9 patients, 9.6%). The most common treatment of recurrences was chemotherapy (5 patients, 36%). The 1-, 3-, and 5-year disease-free survival was 90.9%, 82.7%, and 72.5%, respectively. Median recurrence-free survival was 127 months. The median follow-up for all PNET patients was 25.8 months (range, 1-140 months). The 3-year survival was 97%. The median follow-up of patients after the diagnosis of a recurrence was 13.8 months. The overall survival for those with and without recurrence was 96.3% and 100%, respectively (P = .36). The age ( P = .002) and lymph node ratio ( P |
| Databáze: | OpenAIRE |
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