Amyloid Beta (A4) Precursor Protein: A Potential Biomarker for Recurrent Nasopharyngeal Carcinoma
| Autor: | Zhong-Guo Liang, Kai-Guo Li, Xin-Bin Pan, Hui-Ling Meng, Xiao-Hui Yang, Ling Li, Fanyan Zeng, Xiao-Yu Li, Song Qu, Xiao-Dong Zhu |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Receiver operating characteristic biology Amyloid beta business.industry medicine.medical_treatment medicine.disease Tandem mass tag Radiation therapy 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Nasopharyngeal carcinoma 030220 oncology & carcinogenesis Internal medicine Potential biomarkers medicine biology.protein Biomarker (medicine) Recurrent Nasopharyngeal Carcinoma business |
| Zdroj: | Cancer Management and Research. 11:10651-10656 |
| ISSN: | 1179-1322 |
| DOI: | 10.2147/cmar.s218030 |
| Popis: | Background and aim Nasopharyngeal carcinoma (NPC) is one of the most common cancers in Southern China, Southeast Asia. Radiotherapy is the main treatment for NPC. Still, about 20% of patients with NPC have a recurrence. No effective serum biomarkers are available for recurrent nasopharyngeal carcinoma (rNPC) to date. This study aimed to explore whether amyloid beta (A4) precursor protein (APP) might serve as a valuable diagnostic and prognostic biomarker for patients with rNPC. Methods In a previous study, a tandem mass tag-based proteomic test was performed, which screened 59 differentially expressed proteins (DEPs) between nonrecurrent nasopharyngeal carcinoma (nrNPC) and rNPC. In this study, a protein-protein interaction was conducted to screen the key proteins among the 59 DEPs. APP was validated and evaluated by enzyme-linked immunosorbent assay in 70 serum samples [recurrence (n = 35) and no-recurrence (n = 35)]. Also, the receiver operating characteristic (ROC) curve was plotted to evaluate the predictive value of APP. Results The area under the ROC curve was 0.666 (95% CI: 0.514-0.818, P = 0.044). The best cutoff point of the relative expression levels for APP was 1.23 (concentration = 16.95 ng/mL), at which the sensitivity was 55.2% and the specificity was 90.9%. Conclusion The findings indicated that APP might be a valuable diagnostic and prognostic biomarker for patients with rNPC. |
| Databáze: | OpenAIRE |
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