Lupane triterpenes from the leaves of the tropical rain forest tree Hopea odorata Roxb. and their cytotoxic activities

Autor:	Xavier Cachet, Chavalit Sittisombut, Uthai Sotanaphun, Sylvie Michel, Perayot Pamonsinlapatham, Françoise Raynaud, Malai Satiraphan, Christiane Garbay
Rok vydání:	2012
Předmět:	Dipterocarpaceae biology Chemistry Fractionation Carbon-13 NMR biology.organism_classification Biochemistry Tropical rain forest Terpene Botany Hopea odorata Cytotoxic T cell Two-dimensional nuclear magnetic resonance spectroscopy Ecology Evolution Behavior and Systematics
Zdroj:	Biochemical Systematics and Ecology. 44:407-412
ISSN:	0305-1978
Popis:	Chromatographic fractionation of the cytotoxic n -hexane extract of Hopea odorata Roxb. leaves led to the isolation of eight lupane triterpenes, which constitutes the first report of lupane-type triterpenes from this plant source. Furthermore, 3,30-dioxolup-20(29)-en-28-oic acid ( 6 ) was isolated for the first time from a natural source. Their structures were determined on the basis of spectroscopic methods, including 2D NMR analysis, and by comparison of their spectral data with literature values. Complete NMR assignments of the 1 H and 13 C NMR data were achieved for all compounds. Finally, the cytotoxic activities of the isolated compounds against four human cell lines (PC3, MDA-MB-231, HT-29 and HCT116) was also reported.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ffc27af316ce908bc0d55523d4597bc6 https://doi.org/10.1016/j.bse.2012.05.014 Zobrazit plný text záznamu Full Text from ScienceDirect