Changes in the serum antioxidant system and lipid peroxidation under the influence of asbestos
| Autor: | B. T. Velichkovskii, A. V. Kozlov, E. A. Ostrakhovich, S. K. Soodaeva |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Antioxidant medicine.diagnostic_test medicine.medical_treatment Flavonoid General Medicine medicine.disease_cause medicine.disease General Biochemistry Genetics and Molecular Biology Asbestos Lipid peroxidation chemistry.chemical_compound Rutin Endocrinology Biochemistry chemistry Transferrin Fibrosis Internal medicine medicine Serum iron |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 118:834-836 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/bf02444442 |
| Popis: | The iron content, the state of the serum antioxidant system, and their relationship with the changes in lipid peroxidation in rat liver and lungs at the early stages of chrysotile-asbestos action, and the effect of the naturally occurring flavonoid rutin are studied. Intensification of lipid peroxidation in the liver and lungs and an increase in the oxyproline content, which correlates with the rise in serum antioxidant activity, are observed four weeks after a single intratracheal administration of 50 mg asbestos. The total serum iron content remains unchanged. Rutin has a pronounced anti-asbestos effect, inhibits the early stages of fibrosis, and facilitates normalization of the antioxidant system imbalance induced by asbestos. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink