Physicochemical characterization and in vitro dissolution performance of ibuprofen-Captisol® (sulfobutylether sodium salt of β-CD) inclusion complexes
| Autor: | Sanjoy Kumar Das, Anindya Bose, Nancy Kahali, Jasmina Khanam |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Chemistry
Scanning electron microscope Binding energy 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences Atomic and Molecular Physics and Optics 0104 chemical sciences Electronic Optical and Magnetic Materials Differential scanning calorimetry Distilled water Docking (molecular) Materials Chemistry Physical and Theoretical Chemistry Solubility Fourier transform infrared spectroscopy 0210 nano-technology Spectroscopy Stoichiometry Nuclear chemistry |
| Zdroj: | Journal of Molecular Liquids. 261:239-249 |
| ISSN: | 0167-7322 |
| DOI: | 10.1016/j.molliq.2018.04.007 |
| Popis: | The aim of the present research work was to explore the impact of ibuprofen-captisol® (sulfobutylether sodium salt of β-CD) inclusion complexes on in vitro dissolution performance. Phase solubility studies of ibuprofen using the carrier captisol® had generated AL-type profiles which indicated the formation of 1:1 stoichiometric inclusion complexes. The study revealed that more stable complexes of ibuprofen-captisol® were formed in double distilled water compared to phosphate buffer (pH 7.2) as more fraction of the drug is in un-ionized form. Ibuprofen-captisol® complexes were prepared by (i) kneading and (ii) freeze-drying technique with the various drug-carrier ratio (1:1, 1:3 and 1:5 w/w). Complex formation was explained on the basis of physical mixtures (PMs) of identical compositions. Fourier transform infrared spectroscopy (FT-IR), Differential scanning calorimetry (DSC), X-ray powder diffractometry (XRPD), Scanning electron microscope (SEM) and Molecular docking studies were carried out to establish the inclusion complexation. Molecular docking confirmed the possibility of forming a complex between drug and polymer, and it was evident from the energy-minimized structure of the drug-polymer complex. Minimization of energy suggested the formation of a stable drug-polymer complex with binding energy of (−) 3.6 kcal mol−1. The negative docking energy of the complex formation justifies the reason of its solubility enhancement. The complexes prepared by freeze-drying technique were found to be superior in the enhancement of in vitro dissolution rate of ibuprofen when compared to that of complexes prepared by kneading technique. |
| Databáze: | OpenAIRE |
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