Divergent projections of the paraventricular nucleus of the thalamus mediate the selection of passive and active defensive behaviors
| Autor: | Yogita Chudasama, Jun Ma, Johann du Hoffmann, Mario A. Penzo, Morgan Kindel, B. Sofia Beas |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
genetic structures
General Neuroscience Central nucleus of the amygdala Thalamus Optogenetics Nucleus accumbens Conditioned freezing Biology behavioral disciplines and activities medicine.anatomical_structure mental disorders medicine Paraventricular thalamus Neuroscience Nucleus psychological phenomena and processes Selection (genetic algorithm) |
| Zdroj: | Nature Neuroscience. 24:1429-1440 |
| ISSN: | 1546-1726 1097-6256 |
| DOI: | 10.1038/s41593-021-00912-7 |
| Popis: | The appropriate selection of passive and active defensive behaviors in threatening situations is essential for survival. Previous studies have shown that passive defensive responses depend on activity of the central nucleus of the amygdala (CeA), whereas active ones primarily rely on the nucleus accumbens (NAc). However, the mechanisms underlying flexible switching between these two types of responses remain unknown. Here we show in mice that the paraventricular thalamus (PVT) mediates the selection of defensive behaviors through its interaction with the CeA and the NAc. We show that the PVT-CeA pathway drives conditioned freezing responses, whereas the PVT-NAc pathway is inhibited during freezing and, instead, signals active avoidance events. Optogenetic manipulations revealed that activity in the PVT-CeA or PVT-NAc pathway biases behavior toward the selection of passive or active defensive responses, respectively. These findings provide evidence that the PVT mediates flexible switching between opposing defensive behaviors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink