Human anti‐mouse antibody suppression with cyclosporin A
| Autor: | Sandra B. Wolf, Janet W. Appelbaum, Darrell Salk, Fu-Min Su, Hazel B. Breitz, Christine A. Seiler, Michael J. Bjorn, Mehmet F. Fer, Robert W. Mallett, Paul L. Weiden |
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| Rok vydání: | 1994 |
| Předmět: |
Cancer Research
biology business.industry medicine.drug_class medicine.medical_treatment Murine antibody Pharmacology Monoclonal antibody Oncology Antibodies monoclonal Radioimmunotherapy Cyclosporin a Immunology biology.protein Medicine Human antimouse Antibody Antibody business Human anti-mouse antibody |
| Zdroj: | Cancer. 73:1093-1097 |
| ISSN: | 1097-0142 0008-543X |
| DOI: | 10.1002/1097-0142(19940201)73:3+<1093::aid-cncr2820731349>3.0.co;2-# |
| Popis: | Background. Cyclosporin was used in an attempt to suppress the formation of human antimouse antibody (HAMA) after administration of murine monoclonal antibodies. Methods. Thirteen patients were given oral cyclosporin (8.6-15 mg/kg/day) starting 2 days before administration of technetium-99m ( 99m Tc) labeled F(ab') 2 (3 patients) or Fab (10 patients) murine antibody fragment. Six to nine days later, patients received either rhenium-186 ( 186 Re)-labeled F(ab') 2 or an intact antibody |
| Databáze: | OpenAIRE |
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