High Availability of the α7-Nicotinic Acetylcholine Receptor in Brains of Individuals with Mild Cognitive Impairment: A Pilot Study Using 18F-ASEM PET
| Autor: | Jennifer M. Coughlin, Gwenn S. Smith, Allen R. Chen, Marilyn S. Albert, Laura K. Shinehouse, Erica S. Marshall, Robert F. Dannals, Sarah Frey, Dean F. Wong, Arnold Bakker, Yong Du, Wojciech G. Lesniak, Vidyulata Kamath, Caroline L. Speck, Babak Behnam Azad, Andrew G. Horti, Il Minn, Martin G. Pomper, Leah H. Rubin, Hailey B. Rosenthal, Yuchuan Wang, Jeffrey L. Crawford, Steven P. Rowe |
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| Rok vydání: | 2019 |
| Předmět: |
Oncology
medicine.medical_specialty business.industry Prodromal Stage medicine.disease Pathophysiology 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Internal medicine mental disorders medicine Radioligand Dementia Cholinergic Radiology Nuclear Medicine and imaging Verbal memory business Cognitive impairment 030217 neurology & neurosurgery Acetylcholine receptor |
| Zdroj: | Journal of Nuclear Medicine. 61:423-426 |
| ISSN: | 2159-662X 0161-5505 |
| DOI: | 10.2967/jnumed.119.230979 |
| Popis: | Emerging evidence supports a hypothesized role for the α7-nicotinic acetylcholine receptor (α7-nAChR) in the pathophysiology of Alzheimer's disease. 18F-ASEM (3-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-6-18F-fluorodibenzo[b,d]thiophene 5,5-dioxide) is a radioligand for estimating the availability of α7-nAChR in the brain in vivo with PET. Methods: In this cross-sectional study, 14 patients with mild cognitive impairment (MCI), a prodromal stage to dementia, and 17 cognitively intact, elderly controls completed 18F-ASEM PET. For each participant, binding in each region of interest was estimated using Logan graphical analysis with a metabolite-corrected arterial input function. Results: Higher 18F-ASEM binding was observed in MCI patients than in controls across all regions, supporting higher availability of α7-nAChR in MCI. 18F-ASEM binding was not associated with verbal memory in this small MCI sample. Conclusion: These data support use of 18F-ASEM PET to examine further the relationship between α7-nAChR availability and MCI. |
| Databáze: | OpenAIRE |
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