Long-term outcomes following a diagnosis of ovarian cancer at the time of preventive oophorectomy among BRCA1 and BRCA2 mutation carriers
| Autor: | Ping Sun, Beth Y. Karlan, William D. Foulkes, Elizabeth Hall, Barry P. Rosen, Steven A. Narod, Nadine Tung, Dana Zakalik, Jacek Gronwald, Pål Møller, Jan Lubinksi, Joanne Kotsopoulos, Susan L. Neuhausen |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Obstetrics business.industry medicine.medical_treatment BRCA mutation Obstetrics and Gynecology Oophorectomy Cancer medicine.disease Occult 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Fallopian tube cancer medicine 030212 general & internal medicine Stage (cooking) Ovarian cancer business Fallopian tube |
| Zdroj: | International Journal of Gynecologic Cancer. 30:825-830 |
| ISSN: | 1525-1438 1048-891X |
| DOI: | 10.1136/ijgc-2019-001141 |
| Popis: | IntroductionPreventive bilateral salpingo-oophorectomy is the most effective means of reducing the risk of ovarian cancer among women with an inherited BRCA1 or BRCA2 mutation. Some women are diagnosed with an invasive cancer (ovarian or fallopian tube) at the time of preventive surgery, referred to as an ‘occult’ cancer. The survival experience of these women is not known.MethodsWe estimated the 10-year survival for 52 BRCA mutation carriers diagnosed with an occult ovarian or fallopian tube cancer at the time of preventive bilateral salpingo-oophorectomy.ResultsThe mean age at diagnosis was 51.6 (range 33–69) years. All were serous cancers (although 14 were missing information on histologic subtype). Of the 20 cases with information available on stage at diagnosis, 10 were stage I, 1 was stage II, and 9 were stage III (n=32 missing). After a mean of 6.8 years, 12 women died (23%). The 10-year all-cause survival was 74%.ConclusionAlthough based on only 52 cases, these findings suggest a more favorable prognosis for BRCA mutation carriers diagnosed with an occult rather than incident disease. |
| Databáze: | OpenAIRE |
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