Secondary syphilis associated crescentic glomerulonephritis: A case report
| Autor: | Jonathan E. Zuckerman, Grigoriy Shekhtman, Glenn T. Nagami, Marcelo Santos Sampaio, Mandana Rastegar, Richard Michael Treger |
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| Rok vydání: | 2021 |
| Předmět: |
Sexually transmitted disease
medicine.medical_specialty Treponema biology business.industry medicine.medical_treatment Glomerulonephritis urologic and male genital diseases medicine.disease biology.organism_classification Dermatology Asymptomatic Pathology and Forensic Medicine Membranous nephropathy medicine Rapidly progressive glomerulonephritis Syphilis Hemodialysis medicine.symptom business |
| Zdroj: | Human Pathology Reports. 26:300563 |
| ISSN: | 2772-736X |
| DOI: | 10.1016/j.hpr.2021.300563 |
| Popis: | Introduction Syphilis is a sexually transmitted disease caused by the bacterium Treponema Pallidum and has a diverse clinical presentation, including nephropathies, the most common of which is membranous nephropathy. Crescentic glomerulonephritis is not typically considered to be a manifestation of Syphilis associated renal disease. Case presentation Here we describe an unusual case of crescentic glomerulonephritis associated with secondary syphilis resulting in a rapidly progressing glomerulonephritis presentation requiring hemodialysis. The patient was treated with Penicillin G and intravenous solumedrol. The patient’s kidney function recovered and several months after presentation the patient was asymptomatic off hemodialysis with a serum creatinine of 1.54 mg/dL. Discussion/conclusion Secondary syphilis rarely presents with rapidly progressive glomerulonephritis. This report is only the third such case reported to date of a diffuse necrotizing/crescentic glomerulonephritis resulting from a syphilis infection. As syphilis is on the rise, this report highlights an important differential diagnostic consideration for any necrotizing/crescentic glomerulonephritis. |
| Databáze: | OpenAIRE |
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