Flexible and Modular Syntheses of Enantiopure 5-cis-Substituted Prolinamines from l-Pyroglutamic Acid

Autor:	Benjamin Arensmeyer, Johannes Kaldun, Felix Prause, Benjamin Fröhlich, Dagmar Scharnagel, Benedikt Wennemann, Matthias Breuning
Rok vydání:	2014
Předmět:	chemistry.chemical_compound Enantiopure drug Nitrogen atom Stereochemistry Chemistry Organic Chemistry Pyroglutamic acid Catalysis Pyrrolidine
Zdroj:	Synthesis. 47:575-586
ISSN:	1437-210X 0039-7881
Popis:	A wide range (25 examples) of 5-cis-substituted prolinamines is prepared in five to ten steps starting from cheap l -pyroglutamic acid. Three routes, differing mainly in the order of introduction of the substituents at the 5-cis position, the pyrrolidine nitrogen atom, and the exocyclic amino function, are successfully developed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ff87703eebcba0bc72f15b3e31396926 https://doi.org/10.1055/s-0034-1379457 Zobrazit plný text záznamu