Influence of immediate release tablet formulation on dissolution profile of paracetamol
| Autor: | N Jelena Jovičić-Bata, N Mladena Lalić-Popović, B Nemanja Todorović, S Svetlana Goločorbin-Kon, Ž Boris Milijašević, M Nebojša Pavlović, N Kristina Kermeci |
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| Rok vydání: | 2018 |
| Předmět: |
Analgesic effect
Chromatography Chemistry Phosphate buffered saline Analgesic 02 engineering and technology 021001 nanoscience & nanotechnology 030226 pharmacology & pharmacy 03 medical and health sciences 0302 clinical medicine Zero order kinetics medicine Liberation Immediate release Antipyretic 0210 nano-technology Dissolution medicine.drug |
| Zdroj: | Hospital Pharmacology - International Multidisciplinary Journal. 5:705-714 |
| ISSN: | 2334-9492 |
| DOI: | 10.5937/hpimj1803705t |
| Popis: | Introduction: Paracetamol is analgesic and antipyretic, which is usually in the form of an immediate release tablet formulations. Therapeutic effects in terms of the speed and intensity of the analgesic effect is dependent on speed of liberation from formulation. Aim: The aim of this work was to determine and compare dissolution profiles of 4 paracetamol immediate release tablet formulations and to determine influence of excipients on kinetic of paracetamol dissolution. Materials and Methods: Dissolution profiles of paracetamol tablets were determined using method with paddles and phosphate buffer pH 6.8 as a medium. Release of paracetamol was followed 60 minutes (using 6 time points). Concentration of paracetamol was measured using UV/Vis spectrophotometric method (243 nm). Dissolution profiles were compared using model-independent method (difference factor and similarity factor), statistic method (ANOVA-based method and pair Student's T-test, p |
| Databáze: | OpenAIRE |
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