Garlic Oil Enhances Hepatic and Blood Antioxidants During Hamster Buccal Pouch Carcinogenesis
| Autor: | Sankaran Mirunalini, Siddavaram Nagini, R. Subapriya, R. Kumaraguruparan |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Pharmacology
chemistry.chemical_classification Antioxidant Glutathione peroxidase medicine.medical_treatment Garlic Oil food and beverages Pharmaceutical Science Hamster DMBA Blood lipids General Medicine Glutathione Biology Lipid peroxidation chemistry.chemical_compound Complementary and alternative medicine chemistry Biochemistry Drug Discovery medicine Molecular Medicine |
| Zdroj: | Pharmaceutical Biology. 42:240-245 |
| ISSN: | 1744-5116 1388-0209 |
| DOI: | 10.1080/13880200490514168 |
| Popis: | We analyzed the protective effect of garlic oil on hepatic and blood lipid peroxidation and the antioxidant status during buccal pouch carcinogenesis induced by 7,12-dimethylbenz[a]anthracene (DMBA) in male Syrian hamsters. Enhanced lipid peroxidation in the liver and blood of tumor-bearing animals was accompanied by a significant decrease in antioxidant levels. Topical application of garlic oil effectively suppressed oral carcinomas, decreased lipid peroxidation, and enhanced antioxidant levels. Our results suggest that garlic oil may exert its chemopreventive effects by modulating lipid peroxidation and enhancing antioxidant status in the liver and blood. |
| Databáze: | OpenAIRE |
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