Flow-Based, Cerium Oxide Enhanced, Low-Level Palladium Sonogashira and Heck Coupling Reactions by Perovskite Catalysts

Autor:	Claudio Battilocchio, Benjamin N. Bhawal, Steven V. Ley, Joel M. Hawkins, Rajeev Chorghade, Benjamin J. Deadman
Rok vydání:	2013
Předmět:	Cerium(IV) oxide–cerium(III) oxide cycle Cerium oxide Chemistry Heck reaction Inorganic chemistry chemistry.chemical_element Sonogashira coupling General Chemistry Flow chemistry Heterogeneous catalysis Catalysis Palladium
Zdroj:	Israel Journal of Chemistry. 54:371-380
ISSN:	0021-2148
DOI:	10.1002/ijch.201300049
Popis:	A flow chemistry procedure for Sonogashira and Heck cross-coupling reactions using a low-level palladium perovskite catalyst (LaFe0.95Pd0.05O3) deposited on cerium oxide is reported. The catalyst was generated in situ at high temperature using a flow platform. The system could be applied to a wide range of functionalised substrates, allowing clean and fast delivery of the products within a few minutes (10–30 min), after scavenging with thiourea polymer (QP-TU) and sulfonic acid resin (QP-SA). The use of an in-line evaporator/solvent switching device allowed us to recover the solvent and transport the material into the following stage. The catalyst could be continuously used for at least 24 h, without any noticeable decrease in the catalytic efficiency. In one example the system was scaled to deliver 10 mmol of product.
Databáze:	OpenAIRE
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