Lack of linkage or association between schizophrenia and the polymorphic trinucleotide repeat within the KCNN3 gene on chromosome 1q21

Autor:	Corinne Gehrig, Stylianos E. Antonarakis, J. Jay Gargus, Virginia K. Lasseter, Haig H. Kazazian, K G Chandy, Emmanuelle Fantino, David E. Housman, A. E. Pulver, George A. Gutman, Jean-Louis Blouin, Gerald Nestadt, K. Kalman, Uppala Radhakrishna
Rok vydání:	1999
Předmět:	Genetics Candidate gene Genetic linkage Genetic marker mental disorders Genotype Locus (genetics) Allele Biology Trinucleotide repeat expansion Gene Genetics (clinical)
Zdroj:	American Journal of Medical Genetics. 88:348-351
ISSN:	1096-8628 0148-7299
Popis:	To determine the importance of a candidate gene KCNN3 (formerly named hSKCa3) in the susceptibility to schizophrenia, we have studied the genotypes of a (CAG)n polymorphism within this gene in the DNAs of the members of 54 multiplex families with this disease. Parametric and nonparametric linkage analysis did not provide evidence for linkage between KCNN3 (that we mapped to chromosome 1q21) and schizophrenia. Furthermore, we observed no difference in the distribution of the (CAG)n alleles between affected and normal individuals. These results do not support the hypothesis that larger KCNN3 alleles are preferentially associated with schizophrenia [Chandy et al. 1998 Mol Psychiatr 3:32-37] in individuals from multiply affected families.
Databáze:	OpenAIRE
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