CLE-test with cold air as provocation factor – a feasibility study

Autor: Sandra Stadheim, Signe Bø, Ola Drange Røksund, Håkon Kvidaland, Hege Synnøve Clemm, Jon Andrew Hardie
Rok vydání: 2021
Předmět:
Zdroj: Clinical respiratory physiology, exercise and functional imaging.
DOI: 10.1183/13993003.congress-2021.pa3223
Popis: Introduction: Exercise-induced laryngeal obstruction (EILO) is an important differential diagnosis in exercise-related breathing difficulties. The current gold standard in EILO-diagnostics is the Continuous Laryngoscopy Exercise test (CLE). Although many patients report worsened symptoms during exercise in cold climate, CLE-tests are exclusively performed at room temperature. Aim: We developed a method to investigate if cold air impacts EILO. This study aims to investigate whether having the patient breath cold air (-15⁰C) during CLE-test is feasible and if EILO is aggravated by exercise in cold air. Methods: CLE was used to visualize laryngeal response patterns during two treadmill tests (EIB-protocol 90-95% max. HR over 6 min). Each participant performed two tests at the same speed and incline; one at room temperature and one with cold air from a Turboaire Challenger™ cold air. At 7 Bar pressure, the generator gives 240 l/min at -18°C to -20°C prior to mixing with exhaled breath. Results: Four study participants were included in this study. It was possible to perform the CLE test with simultaneous cold air inhalation. The larynx images were stable and of good quality. The participants reported only minimal discomfort performing the tests. Two participants had a suspected EILO diagnosis before testing. During their cold air test, EILO symptoms seemed to appear earlier in the test with a medialization of laryngeal structures, mainly on the glottic level. Conclusions: The method was feasible and can be used to evaluate whether inhalation of cold air accentuates or quickens the development of EILO. More research is needed.
Databáze: OpenAIRE