ChemInform Abstract: Synthesis and Biological Screening of Some Novel Amidocarbamate Derivatives of Ketoprofen

Autor: Prasanta Kumar Sahoo, Pritishova Behera
Rok vydání: 2010
Předmět:
Zdroj: ChemInform. 41
ISSN: 0931-7597
DOI: 10.1002/chin.201042079
Popis: A series of novel ketoprofen derivatives 4a-j bearing both amide and carbamate functionalities were prepared using benzotriazole. Selective reduction of ketoprofen produced hydroxy derivative 2, which reacts with one or 2 mol of 1-benzotriazole carboxylic acid chloride (1) gave benzotriazole derivatives 3a and 3b respectively. Antioxidative screenings revealed that the prepared compounds 3b and 4a-j possess excellent lipid peroxidation inhibition at 0.1 mM concentration. Two of the compounds 3b and 4 g also showed high soybean lipoxygenase inhibition activity, where as the amidocarbamate derivatives of ketoprofen showed only weak reducing activity against 1,1-diphenyl-2-picrylhydrazyl radicals. No selective antiviral effects were noted for the tested compounds against a broad variety of DNA and RNA viruses.
Databáze: OpenAIRE