Synthesis of Some New Nucleoside Analogues as Potential Antiviral Agents

Autor:	Roger Guedj, M. A. Forestier, J. N. Colin, R. Challand, A.I. Ayi, John Selway, Roger Condom, B. P. Boyode
Rok vydání:	1993
Předmět:	Pyrimidine analogue chemistry.chemical_compound Pyrimidine chemistry Bicyclic molecule Stereochemistry Synthon Genetics Molecule Sodium azide Lithium aluminium hydride Biochemistry Nucleoside
Zdroj:	Nucleosides and Nucleotides. 12:915-924
ISSN:	0732-8311
Popis:	A novel series of pyrimidine nucleoside analogues was synthesized. 2,3-Dideoxy-2,3-anhydro-β-D-lyxofuranose was opened by sodium azide to give the corresponding azido compound, which was reduced by lithium aluminium hydride to lead to 2,3-dideoxy-2,3-epimino-β-D-ribofuranose. Pyrimidine bases were glycosylated with this synthon to give potential antiviral molecules: 1-(2,3-dideoxy-2,3-epimino-β-D-ribofuranosyl)pyrimidines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ff409dede8c939193e79ef2eef8b96d7 https://doi.org/10.1080/07328319308018562 Zobrazit plný text záznamu